...The basic cause of acne is still unknown. It seems to be a multifactorial disease in which interaction of several factors play an important part in the pathogenesis. The primary event may be (a) obstruction of the sebaceous duct due to alteration in the pattern of keratinization within the follicle, (b) abnormal sebum production with excess quantities or altered composition or (c) increased bacterial colonization (proprionibacterium acnes and staphylococcus epidermi¬dis of pilosebaceous follicles which furnish the lipases responsible for hydrolysis of sebum triglycerides into free fatty acids. All three mechanisms may be involved. Obstruction of duct leads to forma¬tion of a comedone, the initial lesion of acne. A comedone can be located either in a closed follicle as a 'white head' consisting of lipid and keratin, or in an open follicle as 'black head' consisting of keratin and lipid with melanin deposition. The continual accumula¬tion of keratin and lipid may lead to rupture of the follicular wall and release of its contents into the surrounding dermis provoking an inflammatory tissue reaction....»
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«...Sensitive Skin can be frustrating for many men and women as it requires patience and understanding as they test new skincare products in their search for an item that does not aggravate or irritate their skin. People with sensitive skin tend to have reactions to a variety of products, reactions that can be quite minor or verge on the extreme side of an allergic reaction, breaking out in a painful rash. People with sensitive skin have a vested interest to look for organic and all natural products that do not contain unnecessary perfumes or additives. ...»
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